Consider whether the screening will be worth any anxiety it might cause, or whether you'll handle your pregnancy differently depending on the results. If your screening test is positive, your doctor will recommend additional testing to make a diagnosis.īefore the screening, think about what the results mean to you. Talk to your health care provider about your screening options.Ī negative quad screen doesn't guarantee that the baby won't have a chromosomal abnormality, single-gene disorder or certain birth defects. Prenatal cell-free DNA screening is another screening method that your health care provider might recommend in place of quad screening. Your health care provider might combine the results of first trimester screening with the quad screen to improve the detection rate of Down syndrome. It was generally used if prenatal care began during the second trimester or if first trimester screening, which involves a blood test and an ultrasound exam, wasn't available.

The quad screen has traditionally been one of the most commonly used screenings in the second trimester. In these birth defects, the baby's intestines or other abdominal organs stick through the belly button. Spina bifida is a birth defect that occurs when a portion of the neural tube fails to develop or close properly, causing defects in the spinal cord and in the bones of the spine. This is a chromosomal disorder that causes severe developmental delays and abnormalities in the structure of the body. Down syndrome is a chromosomal disorder that causes lifelong intellectual disability and developmental delays and, in some people, health problems. The quad screen evaluates your chance of carrying a baby who has any of the following conditions:

Sequential testing in pregnancy